modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method

نویسندگان

abbas akhgari nanotechnology research center and school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran

hasti sadeghi nanotechnology research center and school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran

mohammad ali dabbagh nanotechnology research center and school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran

چکیده

objective(s):the aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. quasi-emulsion solvent diffusion was used as a crystal modification method. materials and methods: corn starch was dissolved in hydrochloric acid at 80˚c and then ethanol as a non-solvent was added with lowering temperature until the formation of a precipitate of modified starch. flow parameters, particle size and thermal behavior of the treated powders were compared with the native starch. finally, the 1:1 mixture of naproxen and each excipient was tabletted, and hardness and friability of different tablets were evaluated. results: larger and well shaped agglomerates were formed which showed different thermal behavior. treated starch exhibited suitable flow properties and tablets made by the treated powder had relatively high hardness. conclusion:  it was found that recrystallization of corn starch by quasi emulsion solvent diffusion method could improve its flowability and compressibility characteristics.

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منابع مشابه

Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method

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Modification of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۷، شماره ۸، صفحات ۵۵۳-۵۵۹

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